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GILTEDX is a medicine used to treat FLT3-mutated acute myeloid leukemia (AML).
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GILTEDX is an antineoplastic inhibitor of RTKs such as FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), AXL (UFO or JTK11), and anaplastic lymphoma kinase (ALK or CD246). GILTEDX binds to and inhibits FLT3, AXL, and ALK in both wild-type and mutant forms. This could impair the FLT3, AXL, and ALK signaling pathways, slowing tumor cell development in cancer cell types that overexpress these RTKs. GILTEDX is used to treat FLT3-mutated acute myeloid leukemia (AML).
FLT3, AXL, and ALK are overexpressed or mutated in many cancer cell types. They're essential for tumor cell proliferation and survival.